Antibacterial Activity And Cytocompatibility Of Phosphonium Chitosan Derivatives

Li-Wei Zheng; Yi-Wei Chen; Chih-Wei Li; Dai-Ling Tsai; Chi-Hsiung Jou

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Original Research Articles · 研究論文

Antibacterial Activity And Cytocompatibility Of Phosphonium Chitosan Derivatives

鏻鹽化幾丁聚醣衍生物抗菌活性與細胞相容性之研究

Li-Wei Zheng 鄭力瑋 Department of Materials and Textiles, Oriental Institute of Technology
Yi-Wei Chen 陳益緯 Department of Materials and Textiles, Oriental Institute of Technology
Chih-Wei Li 李致瑋 Department of Materials and Textiles, Oriental Institute of Technology
Dai-Ling Tsai 蔡岱凌 Department of Materials and Textiles, Oriental Institute of Technology
Chi-Hsiung Jou 周啟雄 ✉ Department of Materials and Textiles, Oriental Institute of Technology

Abstract

In this project, the O-(2-hydroxy) propyl-3-methyl diallyl ammonium chitosan salt (O-HDACS) were applied to make reaction of chitosan and N-epoxy-2,3-propyl-N-methyl-N,N-diallylammonium methyl sulfate (MDAA). Afterwards, two N-quaternary phosphoniun chitosan derivatives (NQPCS) were synthesized by O-HDACS and two (N-carboxyalkyl) triphenylphosphonium of compounds (CATPPs). These NQPCS were characterized by FT-IR. The antibacterial activities of NQPCS were tested by Staphylococcus aureus. The antibacterial activity was evaluated by minimum bactericidal concentration (MBC). NQPCS antioxidant activity were evaluated by DPPH (2,2-diphenyl-1-picryhydrazyl) radical scavenging assay. In addition, the cytocompatibility was evaluated by L929 fibroblast proliferation and cytotoxicity.

Keywords

摘要

本研究係以幾丁聚醣與N-環氧基2,3丙基-N-甲基-N,N-二烯丙基甲基磺酸化銨 (MDAA)反應得到O-(2-羥基) 丙基-3-甲基-二丙烯基氨幾丁聚醣磺酸化物(O-HDACS)，之後O-HDACS分別與2種N-(羧烷基)三苯基溴化鏻化合物(CATPP)進行醯氨化反應而得2種鏻化幾丁聚醣衍生物(NQPCS)。NQPCS的特性以傅立葉轉換紅外光光譜儀(FT-IR)分析其分子結構；以DPPH測定其自由基抑制率。並以金黃色葡萄球菌(Staphylococcus aureus)測試最小殺菌濃度(MBC)。另外，細胞相容性以L929纖維母細胞來評估其細胞成長活性與細胞毒性。

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Issue: Vol. 23 No. 8 (2016)
Section: Original Research Articles
Pages: 477-482
Submitted: 2016-07-07
Published: 2016-12-20
ID: JHGT-16-287
Views: 2
Downloads: 0

引用 How to cite

Zheng, L. W., Chen, Y. W., Li, C. W., Tsai, D. L., & Jou, C. H. (2016). Antibacterial Activity And Cytocompatibility Of Phosphonium Chitosan Derivatives. Journal of the Hwa Gang Textile, 23(8), 477-482. https://www.jhgt.org.tw/article/view/234

@article{zheng2016_234,
  author  = {Zheng, Li-Wei and Chen, Yi-Wei and Li, Chih-Wei and Tsai, Dai-Ling and Jou, Chi-Hsiung},
  title   = {Antibacterial Activity And Cytocompatibility Of Phosphonium Chitosan Derivatives},
  journal = {Journal of the Hwa Gang Textile},
  year    = {2016},
  volume  = {23},
  number  = {8},
  pages   = {477--482},
  issn    = {1025-9678},
  url     = {https://www.jhgt.org.tw/article/view/234}
}

TY  - JOUR
AU  - Zheng, Li-Wei
AU  - Chen, Yi-Wei
AU  - Li, Chih-Wei
AU  - Tsai, Dai-Ling
AU  - Jou, Chi-Hsiung
TI  - Antibacterial Activity And Cytocompatibility Of Phosphonium Chitosan Derivatives
JO  - Journal of the Hwa Gang Textile
T2  - 華岡紡織期刊
VL  - 23
IS  - 8
PY  - 2016
SP  - 477
EP  - 482
KW  - Phosphonium Chitosan Derivatives
KW  - Staphylococcus Aureus
KW  - Antibacterial Activity
KW  - Cytocompatibility
SN  - 1025-9678
UR  - https://www.jhgt.org.tw/article/view/234
AB  - In this project, the O-(2-hydroxy) propyl-3-methyl diallyl ammonium chitosan salt (O-HDACS) were applied to make reaction of chitosan and N-epoxy-2,3-propyl-N-methyl-N,N-diallylammonium methyl sulfate (MDAA). Afterwards, two N-quaternary phosphoniun chitosan derivatives (NQPCS) were synthesized by O-HDACS and two (N-carboxyalkyl) triphenylphosphonium of compounds (CATPPs). These NQPCS were characterized by FT-IR. The antibacterial activities of NQPCS were tested by Staphylococcus aureus. The antibacterial activity was evaluated by minimum bactericidal concentration (MBC). NQPCS antioxidant activity were evaluated by DPPH (2,2-diphenyl-1-picryhydrazyl) radical scavenging assay. In addition, the cytocompatibility was evaluated by L929 fibroblast proliferation and cytotoxicity.
ER  -

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