Cytocompatibility and Antibacterial Activity of Double Cationic Chitoson Quaternary Phosphonium Derivatives

Dai-Ling Tsai; Cheng-Wei Lin; Li-Wei Zheng; Zi-Xuan Zheng; Chi-Hsiung Jou

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Original Research Articles · 研究論文

Cytocompatibility and Antibacterial Activity of Double Cationic Chitoson Quaternary Phosphonium Derivatives

雙陽離子性四級鏻化幾丁聚醣衍生物細胞相容性與抗菌活性之研究

Dai-Ling Tsai 蔡岱凌 Department of Materials and Textiles, Oriental Institute of Technology
Cheng-Wei Lin 林政緯 Department of Materials and Textiles, Oriental Institute of Technology
Li-Wei Zheng 鄭力瑋 Department of Materials and Textiles, Oriental Institute of Technology
Zi-Xuan Zheng 曾子軒 Department of Materials and Textiles, Oriental Institute of Technology
Chi-Hsiung Jou 周啟雄 ✉ Department of Materials and Textiles, Oriental Institute of Technology

Abstract

In this study, the O-(2-hydroxy) propyl-3-methyl diallyl ammonium chitosan salt (O-HDACS) were applied to make reaction of chitosan and N-epoxy-2,3-propyl-N-methyl-N,N-diallylammonium methyl sulfate (MDAA). Afterwards, four double cationic quaternary phosphoniun chitosan derivatives (DCQPCS) were synthesized by O-HDACS and four (N-carboxyalkyl) triphenylphosphonium of compounds (CATPPs). These DCQPCS were characterized by FT-IR. Antioxidant activity were evaluated by DPPH (2,2-diphenyl-1-picryhydrazyl) radical scavenging assay. The cytocompatibility was tested by L929 fibroblast to evaluate proliferation and cytotoxicity. In addition, the antibacterial activity was tested against Staphylococus aureus by calculation of the minimum bactericidal concentrations (MBC).

Keywords

摘要

本研究係以幾丁聚醣與N-環氧基2,3丙基-N-甲基-N,N-二烯丙基甲基磺酸化銨 (MDAA)反應得到O-(2-羥基) 丙基-3-甲基-二丙烯基氨幾丁聚醣磺酸化物(O-HDACS)，之後O-HDACS分別與4種N-(羧烷基)三苯基溴化鏻化合物(CATPP)進行醯氨化反應而得4種雙陽離子性四級鏻化幾丁聚醣衍生物(DCQPCS)。DCQPCS的特性以傅立葉轉換紅外光光譜儀(FT-IR)分析其分子結構，細胞相容性以L929纖維母細胞測試來評估其細胞成長活性與細胞毒性。抗氧化性則以DPPH游?基螯合能力來評估，另外，以金黃色葡萄球菌(Staphylococus aureus)測試最小殺菌濃度來評估抗菌活性。

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Issue: Vol. 25 No. 1 (2018)
Section: Original Research Articles
Pages: 1-6
Submitted: 2017-12-14
Published: 2018-12-03
ID: JHGT-17-459
Views: 2
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引用 How to cite

Tsai, D. L., Lin, C. W., Zheng, L. W., Zheng, Z. X., & Jou, C. H. (2018). Cytocompatibility and Antibacterial Activity of Double Cationic Chitoson Quaternary Phosphonium Derivatives. Journal of the Hwa Gang Textile, 25(1), 1-6. https://www.jhgt.org.tw/article/view/336

@article{tsai2018_336,
  author  = {Tsai, Dai-Ling and Lin, Cheng-Wei and Zheng, Li-Wei and Zheng, Zi-Xuan and Jou, Chi-Hsiung},
  title   = {Cytocompatibility and Antibacterial Activity of Double Cationic Chitoson Quaternary Phosphonium Derivatives},
  journal = {Journal of the Hwa Gang Textile},
  year    = {2018},
  volume  = {25},
  number  = {1},
  pages   = {1--6},
  issn    = {1025-9678},
  url     = {https://www.jhgt.org.tw/article/view/336}
}

TY  - JOUR
AU  - Tsai, Dai-Ling
AU  - Lin, Cheng-Wei
AU  - Zheng, Li-Wei
AU  - Zheng, Zi-Xuan
AU  - Jou, Chi-Hsiung
TI  - Cytocompatibility and Antibacterial Activity of Double Cationic Chitoson Quaternary Phosphonium Derivatives
JO  - Journal of the Hwa Gang Textile
T2  - 華岡紡織期刊
VL  - 25
IS  - 1
PY  - 2018
SP  - 1
EP  - 6
KW  - Quaternary Phosphoniun Chitosan Derivatives
KW  - L929 Fibroblast
KW  - Cytocompatibility
KW  - MTT Test Antioxidant Activity
KW  - Staphylococus Aureus
KW  - Antibacterial Activity
SN  - 1025-9678
UR  - https://www.jhgt.org.tw/article/view/336
AB  - In this study, the O-(2-hydroxy) propyl-3-methyl diallyl ammonium chitosan salt (O-HDACS) were applied to make reaction of chitosan and N-epoxy-2,3-propyl-N-methyl-N,N-diallylammonium methyl sulfate (MDAA). Afterwards, four double cationic quaternary phosphoniun chitosan derivatives (DCQPCS) were synthesized by O-HDACS and four (N-carboxyalkyl) triphenylphosphonium of compounds (CATPPs). These DCQPCS were characterized by FT-IR. Antioxidant activity were evaluated by DPPH (2,2-diphenyl-1-picryhydrazyl) radical scavenging assay. The cytocompatibility was tested by L929 fibroblast to evaluate proliferation and cytotoxicity. In addition, the antibacterial activity was tested against Staphylococus aureus by calculation of the minimum bactericidal concentrations (MBC).
ER  -

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